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DeCS

Descritor Inglês:

STAT Transcription Factors

Descritor Espanhol:

Factores de Transcripción STAT

Descritor Português:

Fatores de Transcrição STAT

Sinônimos Inglês:

STAT (Signal Transducers and Activators of Transcription) Proteins
Transcription Factors, STAT

Categoria:

Definição Inglês:

A family of transcription factors containing SH2 DOMAINS that are involved in CYTOKINE-mediated SIGNAL TRANSDUCTION. STAT transcription factors are recruited to the cytoplasmic region of CELL SURFACE RECEPTORS and are activated via PHOSPHORYLATION. Once activated they dimerize and translocate into the CELL NUCLEUS where they influence GENE expression. They play a role in regulating CELL GROWTH PROCESSES and CELL DIFFERENTIATION. STAT transcription factors are inhibited by SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS and PROTEIN INHIBITORS OF ACTIVATED STAT.

Nota de Indexação Inglês:

general; prefer specifics

Nota Histórica Inglês:

2006

Qualificadores Permitidos Inglês:

Número do Registro:

50795

Identificador Único:

D050791

Similar:

DeCS